Arbekacin is a semi-synthetic aminoglycoside that is used to treat multi-resistant bacterial strains such as Staphylococcus aureus which is known to be methicillian-resistant. Its mechanism of action is to bind irreversibly to the bacterial ribosome 30S and 16S subunits which interferes with the decoding site and wobble base pairing of the tRNA. Due to the interference, the mRNA is misread, causing the wrong amino acid to be inserted creating non-functional or even toxic proteins as a result. If too much arbekacin accumulates it can lead to nephrotoxicity or ototoxicity, this is more prone to occur if arbekacin treatment is used for more than 10 days.

Arbekacin References