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Pathway Description
Ketobemidone
Homo sapiens
Drug Action Pathway
Ketobemidone is an opioid analgesic and is used to treat severe pain such as postoperative, cancer, fractures and kidney stones. It has some NMDA antagonist properties. It is administered intravenously, orally and rectal, and is mainly only used in Scandinavian countries. Compared to morphine it is more effective for analgesia and has a reduced risk of addiction under supervision. Ketobemidone is metabolized by conjugation of phenolic hydroxyl group and by N-methylation, with only roughly 24% excreted unchanged after intravenous administration.
References
Ketobemidone References
National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 10101, Ketobemidone. Retrieved May 27, 2021 from https://pubchem.ncbi.nlm.nih.gov/compound/Ketobemidone.
Jylli L, Lundeberg S, Langius-Eklöf A, Olsson GL. Comparison of the analgesic efficacy of ketobemidone and morphine for management of postoperative pain in children: a randomized, controlled study. Acta Anaesthesiol Scand. 2004 Nov;48(10):1256-9. doi: 10.1111/j.1399-6576.2004.00524.x. PMID: 15504185.
Lundeberg S, Stephanson N, Stiller CO, Eksborg S: Pharmacokinetics after a single intravenous dose of the opioid ketobemidone in neonates. Acta Anaesthesiol Scand. 2012 Sep;56(8):1026-31. doi: 10.1111/j.1399-6576.2012.02726.x. Epub 2012 Jul 26.
Pubmed: 22834454
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