Acenocoumarol is a anticoagulant drug that is used to prevent blood clots to avoid thromboembolic diseases that could result in infarction, ischemic attacks, deep vein thrombosis and myocardial infarction. Acenocoumarol is a derivative from coumarin that is used to inhibit vitamin k reductase, by doing this the carboxylation of vitamin-k depedent factors such as II, VII, IX and X are prevented. As the concentration of reduced form of vitamin K decreases this leads to a depletion of the cofactor for future reactions that are vitamin k dependent. This ultimately leads to interference with coagulation, because of this patients should not give blood during the time they are using Acenocoumarol. Acenocoumarol is rapidly absorbed through oral ingestion and metabolized via oxidation in the liver. Side effects can include bleeding, blood in urine, swelling of clotted blood in the tissue, gastrointestinal bleeding, tachycardia, hypotension, nausea, vomiting, diarrhea and abdominal pains.

Acenocoumarol References