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Pathway Description
Phenprocoumon
Homo sapiens
Drug Action Pathway
Phenprocoumon is an anticoagulant drug that is a derivative of coumarin and is administered via oral ingestion. This is used to prevent and treat any diseases that can cause fatal blood clots that can lead to ischemic strokes in patients. Phenprocoumon inhibits coagulation by antagonizing vitamin K reductase which reduces production of clotting factors. Through inhibition of vitamin k reductase there is a depletion of vitamin K as an available cofactor for carboxylation for future reactions to produce clotting factors. Phenprocoumon is metabolized by hepatic microsomal enzymes cytochrome p-450 and reductases into inactive metabolites and reduced metabolites respectively. Side effects may include blood in stools or urine, excessive bruising, or oozing from any superficial injuries.
References
Phenprocoumon References
National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 54680692, Phenprocoumon. Retrieved July 27, 2021 from https://pubchem.ncbi.nlm.nih.gov/compound/Phenprocoumon.
Schneider KL, Kunst M, Leuchs AK, Bohme M, Weckbecker K, Kastenmuller K, Bleckwenn M, Holdenrieder S, Coch C, Hartmann G, Stingl JC: Phenprocoumon Dose Requirements, Dose Stability and Time in Therapeutic Range in Elderly Patients With CYP2C9 and VKORC1 Polymorphisms. Front Pharmacol. 2020 Jan 28;10:1620. doi: 10.3389/fphar.2019.01620. eCollection 2019.
Pubmed: 32047440
Abduljalil K, Lazar S, Natanzon M, Wu W, Zadoyan G, Steffens B, Kohl V, Morike K, Tomalik-Scharte D, Stingl J, Schwab M, Harenberg J, Gleiter C, Fuhr U: Quantifying the effect of covariates on concentrations and effects of steady-state phenprocoumon using a population pharmacokinetic/pharmacodynamic model. Clin Pharmacokinet. 2013 May;52(5):359-71. doi: 10.1007/s40262-013-0043-z.
Pubmed: 23519598
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