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Pathway Description
Metabolism and Phsyiological Effects of Asymmetric dimethylarginine (ADMA)
Homo sapiens
Metabolic Pathway
Asymmetrical dimethylarginine (ADMA) is produced from L-arginine. L-arginine is obtained from protein-rich foods like red meat, poultry, dairy and eggs. It is absorbed in the intestine to the blood. It enters cells in the body and is metabolized to ADMA via the enzyme protein arginine methyltransferase-1. ADMA inhibits nitric oxide synthase, preventing the formation of nitric oxide. This elevates blood pressure, causes vasoconstriction, impairs endothelium-dependent relaxation, and increases endothelial cell adhesiveness.
References
Metabolism and Phsyiological Effects of Asymmetric dimethylarginine (ADMA) References
Vallance P, Leiper J: Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1023-30. doi: 10.1161/01.ATV.0000128897.54893.26. Epub 2004 Apr 22.
Pubmed: 15105281
Sibal L, Agarwal SC, Home PD, Boger RH: The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease. Curr Cardiol Rev. 2010 May;6(2):82-90. doi: 10.2174/157340310791162659.
Pubmed: 21532773
Teerlink T, Luo Z, Palm F, Wilcox CS: Cellular ADMA: regulation and action. Pharmacol Res. 2009 Dec;60(6):448-60. doi: 10.1016/j.phrs.2009.08.002. Epub 2009 Aug 12.
Pubmed: 19682580
Bode-Böger, S. M., Scalera, F., Kielstein, J. T., Martens-Lobenhoffer, J., Breithardt, G., Fobker, M., & Reinecke, H. (2006). Symmetrical dimethylarginine: A new COMBINED parameter for renal function and extent of coronary artery disease. Journal of the American Society of Nephrology, 17(4), 1128–1134. https://doi.org/10.1681/asn.2005101119
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