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Protein-L- histidine N-pros- methyltransferase L-Histidine S- Adenosylmethionine 1- Methylhistidine S- Adenosylhomocysteine H+ Outer Mitchondrial Membrane Inner Mitocondrial Membrane Cytosol Protein-L-histidine N-pros-methyltransferase otherwise known as METTL9 catalyzes methylation specifically proteins with an HxH motif. Where histidine is followed by x which is any small amino acid follwed by histidine again. METTL9 methylation catalyzes some immunomodulatory proteins in addition to a subunit of mitochondrial respiratory complex I. Cell Membrane