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5'-nucleotidase NT5E 5'-nucleotidase Prostaglandin G/H synthase 2 Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Prostaglandin G/H synthase 1 Solute carrier family 22 member 6 Glycine dehydrogenase [decarboxylating], mitochondrial Acetaminophen Acetaminophen Glycine CO2 3-hydroxy-L- kynurenine 1-Methylhistidine 1-Methylhistidine 4β-methyl-4α- carboxy- cholesta-8,24- dien-3β-ol Heme Heme Heme Heme Pyridoxal 5'-phosphate H-protein, oxidized H-protein, aminomethylated Organic halide tRNA(Ala) 2-oxoglutarate dehydrogenase, E1 component Endoplasmic Reticulum Cytosol Acetaminophen enters the cell via the solute carrier family 22 member 6 transporter. Extracellular space Acetaminophen inhibits COX-1 & COX-2 (prostaglandin G/H synthase 1&2) on the endoplasmic reticulum membrane, preventing the conversion of arachidonic acid into PGH2. Prostaglandin synthesis is reduced. Lowered levels of prostaglandin E2 , which is responsible for pain and fever. This effect on prostaglandin E2 is responsible for the antipyretic and associated with acetaminophen. Inflamed Cell