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Pathway Description
Zolpidem Action Pathway (New)
Homo sapiens
Drug Action Pathway
Zolpidem is a sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency.
Zolpidem binds on the benzodiazepine receptors in the post-synaptic GABA-A ligand-gated chloride channel in different sites of the central nervous system (CNS). This binding will result in an increase on the GABA inhibitory effects which is translated as an increase in the flow of chloride ions into the cell causing hyperpolarization and stabilization of the cellular plasma membrane. Zolpidem binding to the GABAA receptor chloride channel macromolecular complex is thought to lead to the sedative, anticonvulsant, anxiolytic, and myorelaxant drug effects of the drug.
References
Zolpidem Pathway (New) References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Seksel K, Chapter 7 - Behaviour-modifying drugs. Small Animal Clinical Pharmacology 2: 126-147, 2008.
Dodd-Butera T. Broderick M, Diazepam. Encyclopedia of Toxicology 2: 783-785, 2005.
Kandasamy J, Waldemar A. C, 34 - Pharmacologic Therapies IV: Other Medications. Assisted Ventilation of the Neonate 6: 336-379, 2017.
Miller A, McKee A, Mazer C. D. Chapter 4 - Sedation, Analgesia and Related Topics. Cardiothoracic Critical Care 53-70, 2007.
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