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Carbamazepine intestinal transporter Solute carrier family 22 member 1 Carbamazepine iminoquinone transporter Carbamazepine- o-quinione transporter 10,11- Dihydroxycarbamazepine transporter Carbamazepine- 10,11 epoxide glucuronide transporter Carbamazepine glucuronide Cytochrome P450 2B6 Unknown Cytochrome P450 1A2 Unknown Cytochrome P450 3A4 Alcohol dehydrogenase class-3 Epoxide hydrolase 1 Cytochrome P450 3A5 Cytochrome P450 2C19 UDP- glucuronosyltransferase 2B7 UDP- glucuronosyltransferase 2B7 Carbamazepine-O-quinone 10,11-Dihydroxycarbamazepine Carbamazepine glucuronide Carbamazepine iminoquinone Carbamazepine-10,11 epoxide glucoronide Carbamazepine Carbamazepine Carbamazepine Carbamazepine Carbamazepine Carbamazepine iminoquinone Carbamazepine-O-quinone 10,11-Dihydroxycarbamazepine Carbamazepine-10,11 epoxide glucoronide Carbamazepine glucuronide O2 NADPH H+ 3-Hydroxycarbamazepine H2O NADPH 2,3-Dihydroxycarbamazepine NADPH O2 Carbamazepine 2,3-epoxide H2O NADP H+ 2-Hydroxycarbamazepine 2-Hydroxyiminostilbene NAD NADH H+ Carbamazepine-10,11-epoxide H2O O2 NADH H+ H2O NAD O2 NADPH H+ H2O NADP Uridine diphosphate glucuronic acid H+ Uridine 5'-diphosphate Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ Heme Heme Zinc Heme Heme Excretion Heme Endoplasmic Reticulum Cytosol Intestinal Epithelial Cell Hepatocyte Carbamazepine is taken orally
Endoplasmic Reticulum Unknown SLC22A1 Unknown Unknown Unknown Unknown Unknown CYP2B6 Unknown CYP1A2 Unknown CYP3A4 ADH5 EPHX1 CYP3A5 CYP2C19 UGT2B7 UGT2B7 Carbamazepine- O-quinone 10,11- Dihydroxycarbamazepine Carbamazepine glucuronide Carbamazepine iminoquinone Carbamazepine- 10,11 epoxide glucoronide Carbamazepine Carbamazepine Carbamazepine Carbamazepine Carbamazepine Carbamazepine iminoquinone Carbamazepine- O-quinone 10,11- Dihydroxycarbamazepine Carbamazepine- 10,11 epoxide glucoronide Carbamazepine glucuronide Oxygen NADPH Hydrogen Ion 3- Hydroxycarbamazepine Water NADPH 2,3- Dihydroxycarbamazepine NADPH Oxygen Carbamazepine 2,3-epoxide Water NADP Hydrogen Ion 2- Hydroxycarbamazepine 2- Hydroxyiminostilbene NAD NADH Hydrogen Ion Carbamazepine- 10,11-epoxide Water Oxygen NADH Hydrogen Ion Water NAD Oxygen NADPH Hydrogen Ion Water NADP Uridine diphosphate glucuronic acid Hydrogen Ion Uridine 5'-diphosphate Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion Excretion
SLC22A1 CYP2B6 CYP1A2 CYP3A4 ADH5 EPHX1 CYP3A5 CYP2C19 UGT2B7 UGT2B7 CarbOQ 1011dih Car glu CbpImin C-1 e g Carbapn Carbapn Carbapn Carbapn Carbapn CbpImin CarbOQ 1011dih C-1 e g Car glu O2 NADPH H+ 3-HCbmp H2O NADPH 23Dhcmp NADPH O2 Carb23e H2O NADP H+ 2HC 2HI NAD NADH H+ Car1011 H2O O2 NADH H+ H2O NAD O2 NADPH H+ H2O NADP UDPGlcA H+ UDP UDPGlcA UDP H+ Heme Heme Zinc Heme Heme Excre Heme Endoplasmic Reticulum Cytosol Intestinal Epithelial Cell Hepatocyte Carbamazepine is taken orally
Endoplasmic Reticulum SLC22A1 CYP2B6 CYP1A2 CYP3A4 ADH5 EPHX1 CYP3A5 CYP2C19 UGT2B7 UGT2B7 CarbOQ 1011dih Car glu CbpImin C-1 e g Carbapn Carbapn Carbapn Carbapn Carbapn CbpImin CarbOQ 1011dih C-1 e g Car glu O2 NADPH H+ 3-HCbmp H2O NADPH 23Dhcmp NADPH O2 Carb23e H2O NADP H+ 2HC 2HI NAD NADH H+ Car1011 H2O O2 NADH H+ H2O NAD O2 NADPH H+ H2O NADP UDPGlcA H+ UDP UDPGlcA UDP H+ Excre