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Caspase-9 Cytochrome c1, heme protein, mitochondrial Cellular tumor antigen p53 Apoptosis regulator BAX Bcl-2-like protein 11 Cytochrome c1, heme protein, mitochondrial Very unstable ¡¡¡¡ Bcl-2 homologous antagonist/killer Apoptosis regulator BAX Activated hydroxyl radical Phospholipid H2O Lipid Radical O2 Peroxyl Lipid Radical Hydroperoxide Lipid Hydroperoxide Lipid 3,4- Methylenedioxyamphetamine Hydroperoxide Lipid hydroxyl radical Lipid Alhoxyl Radical Phospholipid 1- Methylhistidine Phospholipid Lipid Radical Lipid Radical Phospholipid hydroxyl radical Hydroperoxide Lipid Lipid Radical Lipid Radical Phospholipid Phospholipid Thienylacetate C70 Ascorbic acid Phospholipid α-Tocopherol α-Tocopherol α-Tocopherol Lipid Radical Protein Adducts Protein Adducts Lipid Peroxidation Lipid Peroxidation Unknown signaling cascade Increased permeability inner membrane