PathWhiz

Pathway Description

Prednisone Metabolism Pathway

Homo sapiens

Metabolic Pathway

Prednisone is a synthetic, anti-inflammatory glucocorticoid that derives from cortisone. It is biologically inert and converted to prednisolone in the liver. The glucocorticoid receptor is located intracellularly within the cytoplasm and, upon binding, trans-locates rapidly into the nucleus, where it affects gene transcription and causes inhibition of gene expression and translation for inflammatory leukocytes and structural cells such as epithelium.

References

Prednisone Metabolism Pathway References

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.

Pubmed: 29126136

Puckett Y, Gabbar A, Bokhari AA: Prednisone.

Pubmed: 30521230

Hodgens A, Sharman T: Corticosteroids.

Pubmed: 32119499

Highlighted elements will appear in red.

Highlight Compounds

	Heme
	Hydrogen Ion
	Prednisolone
	Prednisone
	Rilpivirine

Highlight Proteins

	Canalicular multispecific organic anion transporter 2
	Cytochrome P450 3A4
	Solute carrier family 22 member 7

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