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Canalicular multispecific organic anion transporter 2 Solute carrier family 22 member 1 Canalicular multispecific organic anion transporter 2 Cytochrome P450 2D6 Cytochrome P450 2C19 Cytochrome P450 2D6 Cytochrome P450 2D6 Cytochrome P450 2D6 Cytochrome P450 2D6 Cytochrome P450 1A2 Amitriptyline Amitriptyline Amitriptyline Amitriptyline Amitriptyline Amitriptyline Nortriptyline Desmethylnortriptyline E-10- Hydroxydesmethylnortriptyline E-10-Hydroxynortriptyline E-10-Hydroxyamitriptyline E-10- Hydroxydesmethylnortriptyline Heme Heme Heme Heme Heme Heme Heme Endoplasmic Reticulum
Endoplasmic Reticulum ABCC3 SLC22A1 ABCC3 CYP2D6 CYP2C19 CYP2D6 CYP2D6 CYP2D6 CYP2D6 CYP1A2 Amitriptyline Amitriptyline Amitriptyline Amitriptyline Amitriptyline Amitriptyline Nortriptyline Desmethylnortriptyline E-10- Hydroxydesmethylnortriptyline E-10- Hydroxynortriptyline E-10- Hydroxyamitriptyline E-10- Hydroxydesmethylnortriptyline
ABCC3 SLC22A1 ABCC3 CYP2D6 CYP2C19 CYP2D6 CYP2D6 CYP2D6 CYP2D6 CYP1A2 Amitrip Amitrip Amitrip Amitrip Amitrip Amitrip Ateben Desme EH EH EH EH Heme Heme Heme Heme Heme Heme Heme Endoplasmic Reticulum
Endoplasmic Reticulum ABCC3 SLC22A1 ABCC3 CYP2D6 CYP2C19 CYP2D6 CYP2D6 CYP2D6 CYP2D6 CYP1A2 Amitrip Amitrip Amitrip Amitrip Amitrip Amitrip Ateben Desme EH EH EH EH