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Voltage-
dependent
anion-selective
channel protein
1
Mitochondrial
pyruvate
carrier 1
Pyruvate
dehydrogenase
complex
Citrate
synthase,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
alpha,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
beta,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
gamma,
mitochondrial
Oxoglutarate
dehydrogenase
complex
Succinyl-CoA
ligase
Fumarate
hydratase,
mitochondrial
Pyruvate
carboxylase,
mitochondrial
Succinate
dehydrogenase
Aconitate
hydratase,
mitochondrial
Aconitate
hydratase,
mitochondrial
Malate
dehydrogenase,
mitochondrial
Pyruvic acid
Pyruvic acid
Pyruvic acid
CoA
NAD
Acetyl-CoA
CO2
NADH
H2 O
Oxalacetic acid
Citric acid
CoA
Isocitric acid
NAD
Oxoglutaric acid
CO2
NADH
H+
NAD
CoA
Succinyl-CoA
NADH
H+
CO2
Pi
GDP
Succinic acid
CoA
GTP
L-Malic acid
Fumaric acid
H2 O
ATP
HCO3 -
ADP
Pi
Q
FAD
QH2
FADH2
cis-Aconitic acid
H2 O
H2 O
NAD
NADH
H+
Thiamine
pyrophosphate
Lipoamide
FAD
Magnesium
Thiamine
pyrophosphate
Lipoamide
FAD
Biotin
Manganese
4Fe-4S
4Fe-4S
Cytosol
Mitochondrial matrix
Mitochondrion
Inner mitochondrial membrane
Outer mitochondrial membrane
TCA Cycle
Intermembrane space
Mitochondria
VDAC1
MPC1
PDHA1
CS
IDH3A
IDH3B
IDH3G
OGDH
SUCLG1
SUCLG2
FH
PC
SDHA
SDHB
SDHC
SDHD
ACO2
ACO2
MDH2
Pyruvic acid
Pyruvic acid
Pyruvic acid
Coenzyme A
NAD
Acetyl-CoA
Carbon dioxide
NADH
Water
Oxalacetic acid
Citric acid
Coenzyme A
Isocitric acid
NAD
Oxoglutaric
acid
Carbon dioxide
NADH
Hydrogen Ion
NAD
Coenzyme A
Succinyl-CoA
NADH
Hydrogen Ion
Carbon dioxide
Phosphate
Guanosine
diphosphate
Succinic acid
Coenzyme A
Guanosine
triphosphate
L-Malic acid
Fumaric acid
Water
Adenosine
triphosphate
Hydrogen
carbonate
Adenosine
diphosphate
Phosphate
Coenzyme Q10
FAD
QH(2)
FADH
cis-Aconitic
acid
Water
Water
NAD
NADH
Hydrogen Ion
VDAC1
MPC1
PDHA1
CS
IDH3A
IDH3B
IDH3G
OGDH
SUCLG1
SUCLG2
FH
PC
SDHA
SDHB
SDHC
SDHD
ACO2
ACO2
MDH2
Pyr
Pyr
Pyr
CoA
NAD
Ac-CoA
CO2
NADH
H2 O
Oaa
CA
CoA
I-cita
NAD
AKG
CO2
NADH
H+
NAD
CoA
Suc-CoA
NADH
H+
CO2
Pi
GDP
Succini
CoA
GTP
Malate
Fumarat
H2 O
ATP
HCO3 -
ADP
Pi
Q
FAD
QH2
FADH2
Aconiti
H2 O
H2 O
NAD
NADH
H+
ThiamPP
Lipoamd
FAD
Mg2+
ThiamPP
Lipoamd
FAD
Biotin
Mn2+
4Fe-4S
4Fe-4S
Cytosol
Mitochondrial matrix
Mitochondrion
Inner mitochondrial membrane
Outer mitochondrial membrane
TCA Cycle
Intermembrane space
Mitochondria
VDAC1
MPC1
PDHA1
CS
IDH3A
IDH3B
IDH3G
OGDH
SUCLG1
SUCLG2
FH
PC
SDHA
SDHB
SDHC
SDHD
ACO2
ACO2
MDH2
Pyr
Pyr
Pyr
CoA
NAD
Ac-CoA
CO2
NADH
H2O
Oaa
CA
CoA
I-cita
NAD
AKG
CO2
NADH
H+
NAD
CoA
Suc-CoA
NADH
H+
CO2
Pi
GDP
Succini
CoA
GTP
Malate
Fumarat
H2O
ATP
HCO3
ADP
Pi
Coq
FAD
QH(2)
FADH
Aconiti
H2O
H2O
NAD
NADH
H+