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Heme ligase Hemoglobin subunit alpha Hemoglobin subunit beta ATP-binding cassette sub-family C member 3 Hemoglobin subunit alpha Hemoglobin subunit beta Hemoglobin subunit alpha Hemoglobin subunit beta Plasmepsin I Plasmepsin II V-type proton ATPase catalytic subunit A Amodiaquine Amodiaquine Amodiaquine Amodiaquine Amodiaquine Heme β-hematin ATP H2O H+ ADP Pi H+ L-Amino acid Protein degradation pH = 5.0 - 5.4 Digestive vacuole Parasite Erythrocyte Toxic to the parasite Amino acids are used for nutrition and protein synthesis by the parasite Maintains the pH of the vacuole for all enzymes to function Cytosol Amodiaquine inhibits heme ligase, causing the accumulation of toxic free heme Blood Vessel Amodiaquine is taken orally and transported into the blood where Malaria infects erythrocytes
Melanosome Vacuole HDP HBA1 HBB ABCC3 HBA1 HBB HBA1 HBB PMI PMII vapA Amodiaquine Amodiaquine Amodiaquine Amodiaquine Amodiaquine Heme β-hematin Adenosine triphosphate Water Hydrogen Ion Adenosine diphosphate Phosphate Hydrogen Ion L-Amino acid Protein degradation
HDP HBA1 HBB ABCC3 HBA1 HBB HBA1 HBB PMI PMII vapA Amodiaq Amodiaq Amodiaq Amodiaq Amodiaq Heme β-hemat ATP H2O H+ ADP Pi H+ LAA Pro deg pH = 5.0 - 5.4 Digestive vacuole Parasite Erythrocyte Toxic to the parasite Amino acids are used for nutrition and protein synthesis by the parasite Maintains the pH of the vacuole for all enzymes to function Cytosol Amodiaquine inhibits heme ligase, causing the accumulation of toxic free heme Blood Vessel Amodiaquine is taken orally and transported into the blood where Malaria infects erythrocytes
Melanosome Vacuole HDP HBA1 HBB ABCC3 HBA1 HBB HBA1 HBB PMI PMII vapA Amodiaq Amodiaq Amodiaq Amodiaq Amodiaq Heme β-hemat ATP H2O H+ ADP Pi H+ LAA Pro deg