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P-type Ca2+- transporting ATPase ATP-binding cassette sub-family C member 3 Hemoglobin subunit alpha Hemoglobin subunit beta Hemoglobin subunit alpha Hemoglobin subunit beta Hemoglobin subunit alpha Hemoglobin subunit beta Plasmepsin II Plasmepsin I Artenimol Heme Artenimol Artenimol Artenimol Ca+ Ca+ Artenimol Superoxide Carboxyl Radical ATP Oxygen Hydrogen Nitrenium ion Carbamate Artenimol interacts with the heme in the parasitic food vacoule causing the production of radical species, especially a carbon radical species, that damage the parasite. Malaria Cell Cytosol Vacuole Erythrocyte Hydrogen abstraction Artemisinins appear collect in infected erythrocytes, concentrating the drug by several hundred-fold compared to uninfected cells. Artenimol irreversibly binds to and inhibits Ca2+ ATPase pump Blood Vessel
Melanosome Vacuole serca ABCC3 HBA1 HBB HBA1 HBB HBA1 HBB PMII PMI Artenimol Heme Artenimol Artenimol Artenimol Calcium Calcium Artenimol Superoxide Carboxyl Radical Adenosine triphosphate
serca ABCC3 HBA1 HBB HBA1 HBB HBA1 HBB PMII PMI Arten Heme Arten Arten Arten Ca+ Ca+ Arten O2(-) Car Rad ATP O2 H2 Amino Carba Artenimol interacts with the heme in the parasitic food vacoule causing the production of radical species, especially a carbon radical species, that damage the parasite. Malaria Cell Cytosol Vacuole Erythrocyte Hydrogen abstraction Artemisinins appear collect in infected erythrocytes, concentrating the drug by several hundred-fold compared to uninfected cells. Artenimol irreversibly binds to and inhibits Ca2+ ATPase pump Blood Vessel
Melanosome Vacuole serca ABCC3 HBA1 HBB HBA1 HBB HBA1 HBB PMII PMI Arten Heme Arten Arten Arten Ca2+ Ca2+ Arten O2(-) Car Rad ATP