Loader
Loading Pathway...
Succinate dehydrogenase Succinate dehydrogenase Cytochrome b-c1 complex, complex III ADP/ATP translocase Phosphate translocase ATP-binding cassette sub-family C member 3 Glycerol-3- phosphate dehydrogenase, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Glycerol-3- phosphate dehydrogenase [NAD(+)] Glyceraldehyde- 3-phosphate dehydrogenase NADH dehydrogenase [ubiquinone] 1 alpha subcomplex ATP synthase subunit alpha ATP synthase subunit b, mitochondrial Cytochrome c Cytochrome c oxidase complex IV ATP synthase subunit beta ATP synthase subunit epsilon, mitochondrial, putative ATP synthase subunit gamma ATP synthase subunit a ATP synthase subunit delta, mitochondrial, putative Atovaquone Succinic acid Fumaric acid D-Glyceraldehyde 3-phosphate Glyceric acid 1,3-biphosphate ATP ATP ADP ADP ADP ATP Glycerol 3-phosphate Glycerol 3-phosphate Dihydroxyacetone phosphate Dihydroxyacetone phosphate Pi Pi Pi Atovaquone Atovaquone Atovaquone Atovaquone Coenzyme Q10 Ubiquinol-8 Coenzyme Q10 Ubiquinol-8 NADH NAD Pi H+ NADH H+ NAD H+ H+ H+ H+ O2 H+ H+ H2O H+ FAD Heme Heme Copper ATP synthase lipid-binding protein, mitochondrial Citric Acid Cycle Citric Acid Cycle Gluconeogenesis Gluconeogenesis 2 Electrons Fe3+ FAD 2Fe-2S Malaria Cell Cytosol Mitochondria Mitochondrial Matrix Mitochondrial inner membrane Mitochondrial outer membrane Mitochondrial intermembrane space Atovaquone inhibits cytochrome b in the cytochrome bc1 complex (complex III). This inhibits electron transport The inhibition of the electron transport chain prevents the release of energy, therefore it inhibs nucleic acid and ATP synthesis. This eventually leads to cell death.. Atovaquone is taken orally then enters the blood where the parasite is present. Erythrocyte Blood Vessel
Melanosome Mitochondria Unknown Unknown MT-CYB Unknown Unknown ABCC3 Unknown PF3D7_1034400 Unknown PF3D7_1216200 Unknown Unknown PF3D7_0217100 Unknown Unknown MT-CO1 PF3D7_1235700 PF3D7_0715500 PF3D7_1311300 Unknown PF3D7_1147700 Atovaquone Succinic acid Fumaric acid D- Glyceraldehyde 3-phosphate Glyceric acid 1,3-biphosphate Adenosine triphosphate Adenosine triphosphate Adenosine diphosphate Adenosine diphosphate Adenosine diphosphate Adenosine triphosphate Glycerol 3-phosphate Glycerol 3-phosphate Dihydroxyacetone phosphate Dihydroxyacetone phosphate Phosphate Phosphate Phosphate Atovaquone Atovaquone Atovaquone Atovaquone Coenzyme Q10 Ubiquinol-8 Coenzyme Q10 Ubiquinol-8 NADH NAD Phosphate Hydrogen Ion NADH Hydrogen Ion NAD Hydrogen Ion Hydrogen Ion Hydrogen Ion Hydrogen Ion Oxygen Hydrogen Ion Hydrogen Ion Water Hydrogen Ion ATP5G2 Citric Acid Cycle Citric Acid Cycle Gluconeogenesis Gluconeogenesis
MT-CYB ABCC3 PF3D7_1034400 PF3D7_1216200 PF3D7_0217100 MT-CO1 PF3D7_1235700 PF3D7_0715500 PF3D7_1311300 PF3D7_1147700 Acuvel Succini Fumarat Glyc3P GlyABp ATP ATP ADP ADP ADP ATP Glyc1P Glyc1P Dhapp Dhapp Pi Pi Pi Acuvel Acuvel Acuvel Acuvel Coq U8 Coq U8 NADH NAD Pi H+ NADH H+ NAD H+ H+ H+ H+ O2 H+ H+ H2O H+ FAD Heme Heme Cu ATP5G2 PW000005 PW000005 PW000152 PW000152 2 Electrons Fe3+ FAD 2Fe2S Malaria Cell Cytosol Mitochondria Mitochondrial Matrix Mitochondrial inner membrane Mitochondrial outer membrane Mitochondrial intermembrane space Atovaquone inhibits cytochrome b in the cytochrome bc1 complex (complex III). This inhibits electron transport The inhibition of the electron transport chain prevents the release of energy, therefore it inhibs nucleic acid and ATP synthesis. This eventually leads to cell death.. Atovaquone is taken orally then enters the blood where the parasite is present. Erythrocyte Blood Vessel
Melanosome Mitochondria MT-CYB ABCC3 PF3D7_1034400 PF3D7_1216200 PF3D7_0217100 MT-CO1 PF3D7_1235700 PF3D7_0715500 PF3D7_1311300 PF3D7_1147700 Acuvel Succini Fumarat Glyc3P GlyABp ATP ATP ADP ADP ADP ATP Glyc1P Glyc1P Dhapp Dhapp Pi Pi Pi Acuvel Acuvel Acuvel Acuvel Coq U8 Coq U8 NADH NAD Pi H+ NADH H+ NAD H+ H+ H+ H+ O2 H+ H+ H2O H+ ATP5G2 PW000005 PW000005 PW000152 PW000152