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DNA polymerase catalytic subunit ABC transporter, substrate- binding lipoprotein Thymidine kinase Nucleoside diphosphate kinase A dATP Ara-ATP Vidarabine Vidarabine Pi Vidarabine phosphate PPi Magnesium Viral Proteins HHV Infected Cell Integration Nucleus Viral RNA Viral DNA Less Viral DNA is transported into the nucleus, therefore, less viral DNA is integrated into the host DNA. Transcription Translation Less viral proteins produced, fewer viruses can form. Cytosol Ara-ATP also gets incorporated into viral DNA, but since it lacks the 3'-OH group which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, this causes DNA chain termination, preventing the growth of viral DNA. Ara-ATP inhibits the activity of DNA polymerase by competing with its substrate dATP Viral DNA Viral mRNA Viral mRNA Competitor
Nucleus UL30 CDR20291_0805 TK NME1 dATP Ara-ATP Vidarabine Vidarabine Phosphate Vidarabine phosphate Pyrophosphate Viral Proteins
UL30 CDR20291_0805 TK NME1 dATP Ara-ATP Ara-a Ara-a Pi Vid pho PPi Mg2+ Vir Pro HHV Infected Cell Integration Nucleus Viral RNA Viral DNA Less Viral DNA is transported into the nucleus, therefore, less viral DNA is integrated into the host DNA. Transcription Translation Less viral proteins produced, fewer viruses can form. Cytosol Ara-ATP also gets incorporated into viral DNA, but since it lacks the 3'-OH group which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, this causes DNA chain termination, preventing the growth of viral DNA. Ara-ATP inhibits the activity of DNA polymerase by competing with its substrate dATP Viral DNA Viral mRNA Viral mRNA Competitor
Nucleus UL30 CDR20291_0805 TK NME1 dATP Ara-ATP Ara-a Ara-a Pi Vid pho Ppi Vir Pro