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Pathway Description
Oxacillin Action Pathway
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Drug Action Pathway
Oxacillin is a penicillin antibiotic used to treat a number of susceptible bacterial infections.
Oxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Oxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Oxacillin interferes with an autolysin inhibitor.
References
Oxacillin Pathway References
National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 6196, Oxacillin. Retrieved March 20, 2023 from https://pubchem.ncbi.nlm.nih.gov/compound/Oxacillin.
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037
Safrin S (2017). Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics. Katzung B.G.(Ed.), Basic & Clinical Pharmacology, 14e. McGraw-Hill. https://accessmedicine-mhmedical-com.login.ezproxy.library.ualberta.ca/content.aspx?bookid=2249§ionid=175223510
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