PathWhiz

Pathway Description

Cyclacillin Action Pathway

Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Drug Action Pathway

Cyclacillin, a penicillin, is a cyclohexylamido analog of penicillanic acid. Cyclacillin is bactericidal and binds to specific penicillin-binding proteins, thereby inhibiting transpeptidation during peptidoglycan synthesis. This leads to an interruption of the bacterial cell wall, causing instability of bacterial cell wall and results in cell lysis. Cyclacillin is beta-lactamase susceptible.

References

Cyclacillin Pathway References

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037

Safrin S (2017). Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics. Katzung B.G.(Ed.), Basic & Clinical Pharmacology, 14e. McGraw-Hill. https://accessmedicine-mhmedical-com.login.ezproxy.library.ualberta.ca/content.aspx?bookid=2249§ionid=175223510

Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. doi: 10.1128/AAC.18.4.629.

Pubmed: 7447421

Highlighted elements will appear in red.

Highlight Compounds

	Cyclacillin
	NAM-NAG peptide

Highlight Proteins

Penicillin-binding protein 1A

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