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NS3/4A protease Solute carrier organic anion transporter family member 1B1 Genome polyprotein Viroporin p7 Protease NS2 Serine protease/helicase NS3 Non-structural protein 4A Non-structural protein 4B Nonstructural protein 5A Nonstructural protein 5B RNA-directed RNA polymerase Voxilaprevir Voxilaprevir Zinc (II) ion Zinc (II) ion Magnesium Hepatitis C RNA Hepatitis C RNA RNA Replication Zinc (II) ion Magnesium Maturation Translation Endoplasmic Reticulum Hepatitis C Virus Golgi Apparatus Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis Voxilaprevir inhibits NS3/4A protease, which is an enzyme that cleaves the genome polyprotein into 10 proteins required for viral RNA replication. The inhibition of NS3/4A protease prevents the generation of the proteins required for RNA replication. RNA replication cannot occur. RNA is released from the mature Hepatitis C virion and translated at the endoplasmic reticulum into a single Genome polyprotein Ribosome Liver Because RNA replication does not occur, the mature virion is unable to form Viral RNA replication complexes localize to lipid raft-containing, detergent-resistant membranes created by the viral protein NS4B. Infected Hepatocyte
NS3/4A SLCO1B1 Unknown Unknown Unknown Unknown Unknown Unknown NS5A NS5b Unknown Voxilaprevir Voxilaprevir Hepatitis C RNA Hepatitis C RNA
NS3/4A SLCO1B1 NS5A NS5b Voxil Voxil Zinc Zinc Mg2+ He C RN He C RN RNA Replication Zinc Mg2+ Maturation Translation Endoplasmic Reticulum Hepatitis C Virus Golgi Apparatus Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis Voxilaprevir inhibits NS3/4A protease, which is an enzyme that cleaves the genome polyprotein into 10 proteins required for viral RNA replication. The inhibition of NS3/4A protease prevents the generation of the proteins required for RNA replication. RNA replication cannot occur. RNA is released from the mature Hepatitis C virion and translated at the endoplasmic reticulum into a single Genome polyprotein Ribosome Liver Because RNA replication does not occur, the mature virion is unable to form Viral RNA replication complexes localize to lipid raft-containing, detergent-resistant membranes created by the viral protein NS4B. Infected Hepatocyte
NS3/4A SLCO1B1 NS5A NS5b Voxil Voxil He C RN He C RN