PathWhiz

Pathway Description

Maraviroc Action Pathway

Homo sapiens

Drug Action Pathway

Maraviroc, known by the brand name Selzentry or Celsentri, is a chemokine receptor antagonist drug used to treat HIV-1 infections. It was developed by the drug company Pfizer. Maraviroc blocks HIV entry to the host cell by selectively binding to the human chemokine receptor (CCR5) present on the membrane of CD4 cells (T cells). This prevents the interaction of HIV-1 gp120 and CCR5 which is necessary for HIV to enter the cell and replicate.

References

Maraviroc Pathway References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. doi: 10.1038/nrd2199.

Pubmed: 17139284

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. doi: 10.1038/nrd2132.

Pubmed: 17016423

Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. doi: 10.1093/nar/30.1.412.

Pubmed: 11752352

Levy JA: HIV pathogenesis: 25 years of progress and persistent challenges. AIDS. 2009 Jan 14;23(2):147-60. doi: 10.1097/QAD.0b013e3283217f9f.

Pubmed: 19098484

Agrawal-Gamse C, Lee FH, Haggarty B, Jordan AP, Yi Y, Lee B, Collman RG, Hoxie JA, Doms RW, Laakso MM: Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4. J Virol. 2009 Nov;83(21):11005-15. doi: 10.1128/JVI.01238-09. Epub 2009 Aug 19.

Pubmed: 19692476

Napier C, Sale H, Mosley M, Rickett G, Dorr P, Mansfield R, Holbrook M: Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Biochem Pharmacol. 2005 Dec 19;71(1-2):163-72. doi: 10.1016/j.bcp.2005.10.024. Epub 2005 Nov 18.

Pubmed: 16298345

Clark IA, Vissel B: Neurodegenerative disease treatments by direct TNF reduction, SB623 cells, maraviroc and irisin and MCC950, from an inflammatory perspective - a Commentary. Expert Rev Neurother. 2019 Jun;19(6):535-543. doi: 10.1080/14737175.2019.1618710. Epub 2019 May 24.

Pubmed: 31092047

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.

Pubmed: 29126136

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Magnesium
		Maraviroc

Visualize Protein Data

		C-C chemokine receptor type 5
		Envelope glycoprotein gp160
		Gag-Pol polyprotein
		HIV-1 protease
		Integrase
		Reverse transcriptase protein
		Reverse transcriptase/RNaseH
		Surface protein gp120
		Transmembrane protein gp41

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