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Tripartite terminase subunit 2 Tripartite terminase subunit 3 ABC transporter, substrate- binding lipoprotein DNA polymerase catalytic subunit Major DNA-binding protein DNA polymerase processivity factor Alkaline nuclease Cytoplasmic envelopment protein 3 Cytoplasmic envelopment protein 2 Envelope glycoprotein B Envelope glycoprotein H Envelope glycoprotein L DNA polymerase catalytic subunit Major DNA-binding protein DNA polymerase processivity factor Alkaline nuclease Tripartite terminase subunit 1 Tripartite terminase subunit 2 Tripartite terminase subunit 3 Serine/threonine protein kinase UL97 Nuclear egress protein 1 Nuclear egress protein 2 Tripartite terminase subunit 1 Letermovir Letermovir Human Cytomegalovirus DNA Human Cytomegalovirus DNA Human Cytomegalovirus DNA Translation Viral DNA DNA replication Tripartite terminase helps translocate DNA into the viral capsid and cleaves it into correctly sized nucleotides Letermovir inhibits viral terminase which prevents the viral DNA from being translocated into the capsid Nucleus Human cytomegalovirus is translated into all the proteins required for viral assembly and DNA replication, translation, and transcription. Endoplasmic Reticulum Ribosome Due to the inhibition of viral DNA translocation into the capsid, the capsid is left empty Viral proteins assemble and release immature, non-infective virions due to the inhibition of DNA translocation Endocytosis The cytomegalovirus enters the host cell and releases the capsid into the host cell where it is translocated into the nucleus The capsid releases the viral DNA into the nucleus where it is transcripted, replicated, and transferred to the endoplasmic reticulum to be translated Golgi Apparatus Exocytosis Letermovir is taken intravenously or orally
Nucleus TRM2 TRM3 CDR20291_0805 UL54 DBP UL44 UL98 UL99 UL94 gB gH gL UL54 DBP UL44 UL98 TRM1 TRM2 TRM3 UL97 NEC1 NEC2 TRM1 Letermovir Letermovir Human Cytomegalovirus DNA Human Cytomegalovirus DNA Human Cytomegalovirus DNA
TRM2 TRM3 CDR20291_0805 UL54 DBP UL44 UL98 UL99 UL94 gB gH gL UL54 DBP UL44 UL98 TRM1 TRM2 TRM3 UL97 NEC1 NEC2 TRM1 Leter Leter Hu Cy D Hu Cy D Hu Cy D Translation Viral DNA DNA replication Tripartite terminase helps translocate DNA into the viral capsid and cleaves it into correctly sized nucleotides Letermovir inhibits viral terminase which prevents the viral DNA from being translocated into the capsid Nucleus Human cytomegalovirus is translated into all the proteins required for viral assembly and DNA replication, translation, and transcription. Endoplasmic Reticulum Ribosome Due to the inhibition of viral DNA translocation into the capsid, the capsid is left empty Viral proteins assemble and release immature, non-infective virions due to the inhibition of DNA translocation Endocytosis The cytomegalovirus enters the host cell and releases the capsid into the host cell where it is translocated into the nucleus The capsid releases the viral DNA into the nucleus where it is transcripted, replicated, and transferred to the endoplasmic reticulum to be translated Golgi Apparatus Exocytosis Letermovir is taken intravenously or orally
Nucleus TRM2 TRM3 CDR20291_0805 UL54 DBP UL44 UL98 UL99 UL94 gB gH gL UL54 DBP UL44 UL98 TRM1 TRM2 TRM3 UL97 NEC1 NEC2 TRM1 Leter Leter Hu Cy D Hu Cy D Hu Cy D