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Helicase nsp13 Spike glycoprotein Angiotensin- converting enzyme 2 Tixagevimab Replicase polyprotein 1ab Host translation inhibitor nsp1 Non-structural protein 2 Papain-like protease nsp3 Non-structural protein 4 3C-like proteinase nsp5 Non-structural protein 6 Non-structural protein 7 Non-structural protein 8 RNA-capping enzyme subunit nsp9 Non-structural protein 10 Guanine-N7 methyltransferase nsp14 Uridylate- specific endoribonuclease nsp15 2'-O- methyltransferase nsp16 RNA-directed RNA polymerase nsp12 3C-like proteinase nsp5 Papain-like protease nsp3 Zinc (II) ion Chloride ion Manganese Magnesium SARS-CoV-2 RNA SARS-CoV-2 RNA SARS-CoV-2 RNA SARS-CoV-2 RNA RNA Replication Transcription Magnesium Manganese Viral Assembly Translation Endoplasmic Reticulum SARS-CoV-2 Golgi Apparatus SARS-CoV-2 lipoviroparticles are unable to enter the host cell due to inhibition of glycoprotein binding Replicase Protein 1ab is cleaved by SARS-CoV-2 proteinase and protease into various proteins required for infection, especially RdRp polymerase Viral RNA is unable to be released into the host cell Ribosome Due to the inhibition of viral entry into the host cell, viral propagation and replication is unable to occur Infected Pneumocyte SARS-CoV-2 RNA that was released from the virus is normally replicated by RNA polymerase SARS-CoV-2 RNA is translated into Replicase polypotein 1ab by host ribosomes Endocytosis Tixagevimab inhibits SARS-CoV-2 spike glycoprotein which binds to the host cell ACE2 protein in order to bind and enter the host cell Alveolus The inhibition of viral entry prevents RNA replication and translation which further prevents viral assembly and release
rep S ACE2 Unknown rep rep rep Unknown rep rep rep rep Unknown rep rep rep rep rep rep rep Unknown SARS-CoV-2 RNA SARS-CoV-2 RNA SARS-CoV-2 RNA SARS-CoV-2 RNA
rep S ACE2 rep rep rep rep rep rep rep rep rep rep rep rep rep rep Zinc Cl Mn2+ Mg2+ S-C-2 R S-C-2 R S-C-2 R S-C-2 R RNA Replication Transcription Mg2+ Mn2+ Viral Assembly Translation Endoplasmic Reticulum SARS-CoV-2 Golgi Apparatus SARS-CoV-2 lipoviroparticles are unable to enter the host cell due to inhibition of glycoprotein binding Replicase Protein 1ab is cleaved by SARS-CoV-2 proteinase and protease into various proteins required for infection, especially RdRp polymerase Viral RNA is unable to be released into the host cell Ribosome Due to the inhibition of viral entry into the host cell, viral propagation and replication is unable to occur Infected Pneumocyte SARS-CoV-2 RNA that was released from the virus is normally replicated by RNA polymerase SARS-CoV-2 RNA is translated into Replicase polypotein 1ab by host ribosomes Endocytosis Tixagevimab inhibits SARS-CoV-2 spike glycoprotein which binds to the host cell ACE2 protein in order to bind and enter the host cell Alveolus The inhibition of viral entry prevents RNA replication and translation which further prevents viral assembly and release
rep S ACE2 rep rep rep rep rep rep rep rep rep rep rep rep rep rep S-C-2 R S-C-2 R S-C-2 R S-C-2 R