Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Interferon alfa-n1 Action Pathway
Homo sapiens
Drug Action Pathway
Interferon alfa-n1 is a purified and natural (n for natural) alpha interferon from humans. This drug stimulates the innate antiviral response. It is used in the treatment of venereal or genital warts caused by the Human Papilloma Virus (HPV). By binding to the type I interferon receptors (IFNAR1 and IFNAR2c), this drug activates the immune response through the Jak(Janus Kinase)-Stat pathway. In detail, when this interferon binds the IFNAR1 and IFNAR2c, they dimerize, activating two Jak tyrosine kinases. These transphosphorylate themselves and, thus, phosphorylate the receptors. When phosphorylated, the IFNAR1 and IFNAR2c can bind to Stat1 and Stat2 (signal transducers and activators of transcription. They will activate multiple immunomodulatory and antiviral proteins. This drug is available as an intramuscular or subcutaneous injection.
References
Interferon alfa-n1 Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Ishii K, Shinohara M, Sawa M, Kogame M, Higami K, Sano M, Morita T, Sumino Y: Interferon alpha receptor 2 expression by peripheral blood monocytes in patients with a high viral load of hepatitis C virus genotype 1 showing substitution of amino Acid 70 in the core region. Intervirology. 2010;53(2):105-10. doi: 10.1159/000264200. Epub 2009 Dec 3.
Pubmed: 19955815
Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. doi: 10.1093/nar/30.1.412.
Pubmed: 11752352
Krown SE: Interferon treatment of renal cell carcinoma. Current status and future prospects. Cancer. 1987 Feb 1;59(3 Suppl):647-51. doi: 10.1002/1097-0142(19870201)59:3+<647::aid-cncr2820591313>3.0.co;2-#.
Pubmed: 10822464
Tau G, Rothman P: Biologic functions of the IFN-gamma receptors. Allergy. 1999 Dec;54(12):1233-51. doi: 10.1034/j.1398-9995.1999.00099.x.
Pubmed: 10688427
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Downloads
Settings