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Polymerase acidic protein Polymerase basic protein 2 Neuraminidase RNA polymerase Hemagglutinin Neuraminidase Matrix protein 2 Nucleoprotein Non-structural protein 1 Nuclear export protein RNA-directed RNA polymerase catalytic subunit Polymerase basic protein 2 Polymerase acidic protein Polymerase basic protein 2 Polymerase acidic protein RNA polymerase N-Acetylneuraminic acid Zanamivir Calcium Manganese Calcium Manganese Manganese Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Endocytosis Viral RNA Viral mRNA RNA replication Zanamivir inhibits viral neuraminidase, preventing the release of new viral particles into the host body Viral RNA is released from the viral cell and transported into the host nucleus Translation Viral RNA and viral proteins are assembled at the host plasma membrane Assembly Budding & Release Respiratory Epithelial Cell Viral Neuraminidase helps viruses to be released from the plasma membrane of the host cell after budding by cleaving terminal sialic acid resides from glycan structures on the surface of the infected cell. Viral mRNA is translated into various proteins required for viral replication and infection Cytosol Nucleus Lungs
Nucleus PA PB2 NA PB1 HA NA M NP NS NS PB1 PB2 PA PB2 PA PB1 N- Acetylneuraminic acid Zanamivir Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA
PA PB2 NA PB1 HA NA M NP NS NS PB1 PB2 PA PB2 PA PB1 Neu5Ac Zmr Ca2+ Mn2+ Ca2+ Mn2+ Mn2+ I A v A I A v A I A v A I A v A I A v A I A v A Endocytosis Viral RNA Viral mRNA RNA replication Zanamivir inhibits viral neuraminidase, preventing the release of new viral particles into the host body Viral RNA is released from the viral cell and transported into the host nucleus Translation Viral RNA and viral proteins are assembled at the host plasma membrane Assembly Budding & Release Respiratory Epithelial Cell Viral Neuraminidase helps viruses to be released from the plasma membrane of the host cell after budding by cleaving terminal sialic acid resides from glycan structures on the surface of the infected cell. Viral mRNA is translated into various proteins required for viral replication and infection Cytosol Nucleus Lungs
Nucleus PA PB2 NA PB1 HA NA M NP NS NS PB1 PB2 PA PB2 PA PB1 Neu5Ac Zmr I A v A I A v A I A v A I A v A I A v A I A v A