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Polymerase acidic protein RNA-directed RNA polymerase catalytic subunit Polymerase basic protein 2 RNA-directed RNA polymerase catalytic subunit Polymerase basic protein 2 Polymerase acidic protein Multidrug resistance- associated protein 4 Nucleoside diphosphate kinase A ADP- ribosylation factor 6 RNA-directed RNA polymerase catalytic subunit Polymerase basic protein 2 Polymerase acidic protein Hemagglutinin Neuraminidase Matrix protein 2 Nucleoprotein Non-structural protein 1 Nuclear export protein RNA-directed RNA polymerase catalytic subunit Polymerase basic protein 2 Polymerase acidic protein Ribavirin triphosphate Ribavirin triphosphate Ribavirin Ribavirin Pi Manganese Manganese Magnesium Manganese Calcium Manganese Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Endocytosis Viral RNA Viral mRNA RNA replication Rimantadine inhibits matrix protein 2 on the influeza virus, which is responsible for the uncoating of the virus. The inhibition of the synthesis of mRNA prevents the translation of mRNA into required viral proteins Translation Viral RNA and viral proteins are unable to be assembled or released due to the inhibition of viral RNA polymerase Assembly Budding & Release Respiratory Epithelial Cell Cytosol Nucleus Ribavirin triphosphate inhibits viral RNA polymerase which prevents RNA replication and synthesis of mRNA
PA PB1 PB2 PB1 PB2 PA ABCC4 NME1 ARF6 PB1 PB2 PA HA NA M NP NS NS PB1 PB2 PA Ribavirin triphosphate Ribavirin triphosphate Ribavirin Ribavirin Phosphate Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA
PA PB1 PB2 PB1 PB2 PA ABCC4 NME1 ARF6 PB1 PB2 PA HA NA M NP NS NS PB1 PB2 PA Rib tri Rib tri Rbv Rbv Pi Mn2+ Mn2+ Mg2+ Mn2+ Ca2+ Mn2+ I A v A I A v A I A v A I A v A I A v A I A v A Endocytosis Viral RNA Viral mRNA RNA replication Rimantadine inhibits matrix protein 2 on the influeza virus, which is responsible for the uncoating of the virus. The inhibition of the synthesis of mRNA prevents the translation of mRNA into required viral proteins Translation Viral RNA and viral proteins are unable to be assembled or released due to the inhibition of viral RNA polymerase Assembly Budding & Release Respiratory Epithelial Cell Cytosol Nucleus Ribavirin triphosphate inhibits viral RNA polymerase which prevents RNA replication and synthesis of mRNA
PA PB1 PB2 PB1 PB2 PA ABCC4 NME1 ARF6 PB1 PB2 PA HA NA M NP NS NS PB1 PB2 PA Rib tri Rib tri Rbv Rbv Pi I A v A I A v A I A v A I A v A I A v A I A v A