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Pathway Description
Estazolam Action Pathway
Homo sapiens
Drug Action Pathway
Estazolam is a benzodiazepine used for the short-term management of insomnia. Estazolam, a triazolobenzodiazepine derivative, is an oral hypnotic agent with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Some side effects of using estazolam may include grogginess, weakness, dry mouth, and constipation.
References
Estazolam Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Akbarzadeh T, Tabatabai SA, Khoshnoud MJ, Shafaghi B, Shafiee A: Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists. Bioorg Med Chem. 2003 Mar 6;11(5):769-73. doi: 10.1016/s0968-0896(02)00469-8.
Pubmed: 12538007
Kirkwood CK: Management of insomnia. J Am Pharm Assoc (Wash). 1999 Sep-Oct;39(5):688-96; quiz 713-4. doi: 10.1016/s1086-5802(15)30354-5.
Pubmed: 10533351
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