Lormetazepam is a benzodiazepine indicated in the treatment of anxiety and the induction of anesthesia. Lormatazepam is an orally available benzodiazepine used in the UK for the treatment of short-term insomnia. It can be found under the brand names Noctamid, Aldosomnil, Ergocalm, and Metatop. Lormetazepam is a benzodiazepine which reduces central nervous system (CNS) activity. It produces anxiolytic, muscle relaxant, sedative and hypnotic effects. Because it is a short-acting benzodiapine, it does not produce significant sedation after waking. Lormetazepam, as a benzodiazepine, binds to the regulatory site between the α and γ subunits of γ-aminobutryic acid (GABA) A receptors with γ2 and α1, α2, α3, or α5 subunits. This facilitates the opening of the chloride channel allowing chloride ions to flow into the neuron resulting in hyperpolarization. Hyperpolarized neurons require greater simulation to reach their action potential threshold. The general inhibitory effect on neuronal depolarization produces the effects of lormetazepam. Some side effects of using lormetazepam may include aggression, lightheadedness, confusion, and headache.

Lormetazepam Pathway References