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Pathway Description
Prazepam Action Pathway
Homo sapiens
Drug Action Pathway
Prazepam is a benzodiazepine used to manage more severe forms of anxiety disorders. Prazepam is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant activity. It can be found under the brand names Centrac, Demetrin, and Prazene. Benzodiazepines may be habit-forming (causing mental or physical dependence), especially when taken for a long time or in high doses. Prazepam is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation. Prazepam is a prodrug for desmethyldiazepam which is responsible for the therapeutic effects of prazepam. Some side effects of using prazepam may include drowsiness, confusion, coordination problems, and concentration and memory problems.
References
Prazepam Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Jacqmin P, Ansseau M: Comparison of sublingual and oral prazepam in normal subjects. II. Pharmacokinetic and pharmacodynamic data. Neuropsychobiology. 1988;19(4):186-91. doi: 10.1159/000118458.
Pubmed: 2854609
Quast U: [Molecular mechanism of action of benzodiazepines]. Fortschr Med. 1981 May 28;99(20):788-94.
Pubmed: 6114911
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