PathWhiz

Pathway Description

Bemiparin Action Pathway

Homo sapiens

Drug Action Pathway

Bemiparin is a heparin characterized by its ultra-low molecular weight (LMWH) due to the molecular mass having a low mean of 3600 daltons. Bemiparin has a lower anti-thrombin activity than traditional LMWH. The mechanism of action of the antithrombotic acts mainly on factor Xa to prevent thromboembolism following surgery. Factor Xa is necessary for the formation of a thrombus, it acts to increase coagulation by converting prothrombin to thrombin. Administered through subcutaneous injections, it is rapidly absorbed with a half-life of 5-6 hours. It is excreted through hepatic and renal routes, elimination of the drug is impaired if there are issues with the renal or hepatic systems. Some precautions is that Bemiparin may suppress the adrenal secretion of aldosterone and lead to elevated potassium.

References

Bemiparin Pathway References

Chapman TM, Goa KL: Bemiparin: a review of its use in the prevention of venous thromboembolism and treatment of deep vein thrombosis. Drugs. 2003;63(21):2357-77. doi: 10.2165/00003495-200363210-00009.

Pubmed: 14524738

Planes A: Review of bemiparin sodium--a new second-generation low molecular weight heparin and its applications in venous thromboembolism. Expert Opin Pharmacother. 2003 Sep;4(9):1551-61. doi: 10.1517/14656566.4.9.1551.

Pubmed: 12943485

Jeske WP, Hoppensteadt D, Gray A, Walenga JM, Cunanan J, Myers L, Fareed J, Bayol A, Rigal H, Viskov C: A common standard is inappropriate for determining the potency of ultra low molecular weight heparins such as semuloparin and bemiparin. Thromb Res. 2011 Oct;128(4):361-7. doi: 10.1016/j.thromres.2011.03.001. Epub 2011 Apr 2.

Pubmed: 21458847

Highlighted elements will appear in red.

Highlight Compounds

	Bemiparin
	Calcium

Highlight Proteins

	Antithrombin-III
	Coagulation factor X
	Fibrinogen alpha chain
	Fibrinogen beta chain
	Fibrinogen gamma chain
	Thrombin

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data