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Coagulation factor VII Tissue factor Tissue factor Fibrin (loose) Fibrin (loose) Fibrin (loose) Fibrin (mesh) Fibrin (mesh) Fibrin (mesh) Coagulation factor XIII A chain Coagulation factor XIIIa Coagulation factor XIII B chain Coagulation factor XIa Coagulation factor IX Prothrombin Coagulation factor VIII Coagulation factor V Coagulation factor IX Coagulation factor X Coagulation factor X Prothrombin Thrombin Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Vitamin K epoxide reductase complex subunit 1 Vitamin K-dependent gamma- carboxylase Fibrin degradation products Plasminogen Coagulation factor X Coagulation factor VIII Coagulation factor V Coagulation factor VIIa Vitamin K1 2,3-epoxide Reduced Vitamin K (phylloquinone) Calcium Calcium Calcium Precursors of Prothrombin and coagulation factors VII, IX, ad X Prothrombin and coagulation factors VII, IX and X Calcium Calcium Calcium Calcium Calcium Calcium Tenase Complex Prothrombinase Complex Extrinsic Pathway Vascular Injury At the site of injury collagen and tissue factor are exposed to coagulation factors in the blood activating the extrinsic and intrinsic pathways. Prothrombin and coagulation factors VII, ,IX and X are transported via golgi apparatus vesicles into the blood. Extracellular Space Hepatocyte Endoplasmic Reticulum Membrane Cytosol Golgi Apparatus The fibrin mesh/clot forms at the site of vascular injury, blocking the leaking blood. Blood Vessel
Endoplasmic Reticulum Melanosome F7 Unknown Unknown Unknown Unknown FGG Unknown Unknown FGG F13A1 Unknown Unknown Unknown F9 Unknown F8 F5 F9 F10 F10 Unknown Unknown Unknown Unknown FGG VKORC1 GGCX FGG PLG F10 F8 F5 F7 Vitamin K1 2,3-epoxide Reduced Vitamin K (phylloquinone) Precursors of Prothrombin and coagulation factors VII, IX, ad X Prothrombin and coagulation factors VII, IX and X
F7 FGG FGG F13A1 F9 F8 F5 F9 F10 F10 FGG VKORC1 GGCX FGG PLG F10 F8 F5 F7 VitKo ReVitK Ca2+ Ca2+ Ca2+ POPACFV PACFVIA Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Tenase Complex Prothrombinase Complex Extrinsic Pathway Vascular Injury At the site of injury collagen and tissue factor are exposed to coagulation factors in the blood activating the extrinsic and intrinsic pathways. Prothrombin and coagulation factors VII, ,IX and X are transported via golgi apparatus vesicles into the blood. Extracellular Space Hepatocyte Endoplasmic Reticulum Membrane Cytosol Golgi Apparatus The fibrin mesh/clot forms at the site of vascular injury, blocking the leaking blood. Blood Vessel
Endoplasmic Reticulum Melanosome F7 FGG FGG F13A1 F9 F8 F5 F9 F10 F10 FGG VKORC1 GGCX FGG PLG F10 F8 F5 F7 VitKo ReVitK POPACFV PACFVIA