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Pathway Description
Nitrendipine Action Pathway (New)
Homo sapiens
Drug Action Pathway
Nitrendipine is a dihydropyridine calcium channel blocker indicated in the treatment of arterial hypertension. Nitrendipine is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nitrendipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes. It targets the alpha-1C, alpha-2/delta-1, beta-2, alpha-1D, and alpha-1S subunits of the channel. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. Nitrendipine is administered as an oral tablet. Some side effects of using nitrendipine may include headache, flushing, anxiety, and dizziness.
References
Nitrendipine Pathway (New) References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Trouve R, Nahas G: Nitrendipine: an antidote to cardiac and lethal toxicity of cocaine. Proc Soc Exp Biol Med. 1986 Dec;183(3):392-7. doi: 10.3181/00379727-183-3-rc1.
Pubmed: 3797422
Peterson BZ, Tanada TN, Catterall WA: Molecular determinants of high affinity dihydropyridine binding in L-type calcium channels. J Biol Chem. 1996 Mar 8;271(10):5293-6. doi: 10.1074/jbc.271.10.5293.
Pubmed: 8621376
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