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Proton-coupled folate transporter Tetrahydrofolic Acid Transporter Mitochondrial folate transporter/carrier Folate receptor beta Folate receptor beta Dihydrofolate reductase Dihydrofolate reductase Gamma-glutamyl hydrolase Monofunctional C1- tetrahydrofolate synthase, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Tetrahydrofolic acid 5,10-Methylene-THF Folic acid Folic acid Tetrahydrofolic acid Tetrahydrofolic acid Pafolacianine Pafolacianine Dihydrofolic acid NADP NADPH NADPH NADP Tetrahydrofolyl-[Glu](n) H2O L-Glutamic acid ATP Formic acid ADP 10-Formyltetrahydrofolate Pi H+ 5,10-Methenyltetrahydrofolic acid H2O NADH NAD Magnesium Purine Metabolism Histidine Metabolism Methionine Metabolism Glycine and Serine Metabolism Glycine and Serine Metabolism Magnesium Extracellular Space Cytosol Lysosome Mitochondria 5,10-Methylene-THF, is an intermediate in many amino acid pathways, such as methionine synthesis. It is also used in thymidine synthesis which is a nucleoside needed for DNA replication Cancer Cell Pafolacianine is administered intravenously and travels to its targets within the body Pafolacianine, folate analogue that binds to folate receptors and fluoresces. In cancer cells, folate receptors are overexpressed and the drug accumulates within the cells showing the tumor location
Lysosome Mitochondria SLC46A1 Unknown SLC25A32, MFT, MFTC FOLR2 FOLR2 DHFR DHFR GGH MTHFD1L MTHFD2 MTHFD2 Tetrahydrofolic acid 5,10- Methylene-THF Folic acid Folic acid Tetrahydrofolic acid Tetrahydrofolic acid Pafolacianine Pafolacianine Dihydrofolic acid NADP NADPH NADPH NADP Tetrahydrofolyl- [Glu](n) Water L-Glutamic acid Adenosine triphosphate Formic acid Adenosine diphosphate 10- Formyltetrahydrofolate Phosphate Hydrogen Ion 5,10- Methenyltetrahydrofolic acid Water NADH NAD Purine Metabolism Histidine Metabolism Methionine Metabolism Glycine and Serine Metabolism Glycine and Serine Metabolism
SLC46A1 SLC25A32, MFT, MFTC FOLR2 FOLR2 DHFR DHFR GGH MTHFD1L MTHFD2 MTHFD2 THFA 5XM-THF Folate Folate THFA THFA Pafol Pafol FAH2 NADP NADPH NADPH NADP ThGluN H2O Glu ATP Formate ADP 10-FTHF Pi H+ CH-THF H2O NADH NAD Mg2+ PW000052 PW000043 PW000056 PW000157 PW000157 Mg2+ Extracellular Space Cytosol Lysosome Mitochondria 5,10-Methylene-THF, is an intermediate in many amino acid pathways, such as methionine synthesis. It is also used in thymidine synthesis which is a nucleoside needed for DNA replication Cancer Cell Pafolacianine is administered intravenously and travels to its targets within the body Pafolacianine, folate analogue that binds to folate receptors and fluoresces. In cancer cells, folate receptors are overexpressed and the drug accumulates within the cells showing the tumor location
Lysosome Mitochondria SLC46A1 SLC25A32, MFT, MFTC FOLR2 FOLR2 DHFR DHFR GGH MTHFD1L MTHFD2 MTHFD2 THFA 5XM-THF Folate Folate THFA THFA Pafol Pafol FAH2 NADP NADPH NADPH NADP ThGluN H2O Glu ATP Formate ADP 10-FTHF Pi H+ CH-THF H2O NADH NAD PW000052 PW000043 PW000056 PW000157 PW000157