Nilvadipine is a calcium channel blocker used to manage arterial hypertension. For the management of vasospastic angina, chronic stable angina and hypertension. Nilvadipine is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nilvadipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in an increase of myocardial oxygen supply and a decrease in systemic blood pressure. Nilvadipine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. Nilvadipine targets the alpha-1C, alpha-2/delta-1, and beta-2 subunits of the channel, and it is administered as on oral tablet. Possible side effects of using nilvadipine may include headache, dizziness, fatigue, and flushing.

Nilvadipine Pathway References