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Pathway Description
Desipramine Action Pathway (New)
Homo sapiens
Drug Action Pathway
Desipramine, also known as Norpramin, is a dibenzazepine-derivative tricyclic antidepressant (TCA) used in the treatment of depression. In non-depressed individuals, desipramine does not affect mood but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. Secondary amine TCAs, such as desipramine, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs. It can also be used to manage chronic neuropathic pain, as a second-line agent for the management of anxiety disorders, and as a second or third-line agent in ADHD management. This drug is the active metabolite of imipramine, a tertiary amine TCA. It binds to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter of the presynaptic neurons. In consequence, there is a high concentration of those two neurotransmitters in the synapses. This molecule is administered as an oral tablet.
References
Desipramine Pathway (New) References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Weinshenker D, White SS, Javors MA, Palmiter RD, Szot P: Regulation of norepinephrine transporter abundance by catecholamines and desipramine in vivo. Brain Res. 2002 Aug 16;946(2):239-46. doi: 10.1016/s0006-8993(02)02889-5.
Pubmed: 12137927
Bryan-Lluka LJ, Bonisch H, Lewis RJ: chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter. J Biol Chem. 2003 Oct 10;278(41):40324-9. doi: 10.1074/jbc.M213101200. Epub 2003 Jul 1.
Pubmed: 12837768
Ordway GA, Jia W, Li J, Zhu MY, Mandela P, Pan J: Norepinephrine transporter function and desipramine: residual drug effects versus short-term regulation. J Neurosci Methods. 2005 Apr 30;143(2):217-25. doi: 10.1016/j.jneumeth.2004.11.006. Epub 2004 Dec 30.
Pubmed: 15814154
Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. doi: 10.1016/s0014-2999(97)01393-9.
Pubmed: 9537821
Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. doi: 10.1007/BF02244985.
Pubmed: 7855217
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