Neostigmine is a cholinesterase inhibitor used to treat myasthenia gravis and to try to combat muscle atrophy. By inhibiting the acetylcholinesterase enzyme, it can no longer breakdown acetylcholine allowing it to further interact with the nicotinic and muscarinic receptors.
Luo J, Chen S, Min S, Peng L: Reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockade. Ther Clin Risk Manag. 2018 Dec 10;14:2397-2406. doi: 10.2147/TCRM.S179420. eCollection 2018.
Valle RG, Godoy FL: Neostigmine for acute colonic pseudo-obstruction: A meta-analysis. Ann Med Surg (Lond). 2014 Jun 19;3(3):60-4. doi: 10.1016/j.amsu.2014.04.002. eCollection 2014 Sep.
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