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Pathway Description
Vilazodone mechanism of Action Action Pathway
Homo sapiens
Drug Action Pathway
Vilazodone selectively inhibits serotonin reuptake in the central nervous system as well as acting as a partial agonist of 5HT-1A receptors. The exact mechanism for how these effects translate to its antidepressant effects are not known though there is an association between these effects and anti-depressive activity.
References
Vilazodone mechanism of Action Pathway References
Shin JJ, Saadabadi A: Trazodone.
Pubmed: 29262060
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Sangkuhl K, Klein TE, Altman RB: Selective serotonin reuptake inhibitors pathway. Pharmacogenet Genomics. 2009 Nov;19(11):907-9. doi: 10.1097/FPC.0b013e32833132cb.
Pubmed: 19741567
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