Argatroban is a synthetic direct thrombin inhibitor it is recommended for people who have a risk for heparin-induced thrombocytopenia (HIT). The mechanism of action is done by inhibiting thrombin-catalyzed reactions like fibrin formation, it inhibits prothrombin so that fibrin cannot form stopping the formation of a clot. Argatroban is metabolized by the liver through hydroxylation and aromatization. Commonly administered through intravenous injection with a half-life of 30 - 60 minutes and is primarily excreted through the feces, bile and urine. It can interact with food products so it is best to avoid herbs and supplements with anticoagulant and antiplatelet activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. Extreme caution with grapefruit products as grapefruit inhibits CYP3A4 metabolism, this enzyme is responsible for metabolizing argatroban leading to increased concentration in the blood. Extreme caution should also be taken with St. John's Wort as it can interact with the drug.

Argatroban Pathway References