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Amidophosphoribosyltransferase Ras-related C3 botulinum toxin substrate 1 Equilibrative nucleoside transporter 1 Sodium/nucleoside cotransporter 2 Hypoxanthine- guanine phosphoribosyltransferase Inosine-5'- monophosphate dehydrogenase 1 GMP synthase [glutamine- hydrolyzing] Ribose- phosphate pyrophosphokinase 3 Trifunctional purine biosynthetic protein adenosine-3 Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylformylglycinamidine synthase Purine nucleoside phosphorylase Purine nucleoside phosphorylase Thiopurine S- methyltransferase 6-Methylthiopurine 5'-monophosphate ribonucleotide Thioguanosine 5'-triphosphate Thiodeoxyguanosine-5'- triphosphate Guanosine Guanine Adenine Phosphoribosylformylglycineamidine Mercaptopurine Mercaptopurine Mercaptopurine Phosphoribosyl pyrophosphate 6-Thioinosine-5'-monophosphate NAD H2O Thioxanthine monophosphate NADH L-Glutamine H2O ATP 6-Thioguanosine monophosphate AMP PPi Thioguanosine 5'-diphosphate Thiodeoxyguanosine 5'-diphosphate D-Ribose 5-phosphate ATP Phosphoribosyl pyrophosphate AMP 5-Phosphoribosylamine PPi L-Glutamic acid L-Glutamine H2O ATP Glycine ADP Pi Glycineamideribotide 10-Formyltetrahydrofolate Tetrahydrofolic acid 5'-Phosphoribosyl-N- formylglycinamide ATP L-Glutamine H2O ADP Phosphoric acid L-Glutamic acid Adenosine Pi Ribose 1-phosphate Pi Ribose 1-phosphate S-Adenosylmethionine S-Adenosylhomocysteine Na+ Na+ Potassium DNA Synthesis Regulation of Apoptosis of Activated T Cells DNA and RNA Synthesis DNA and RNA Synthesis DNA and RNA Synthesis Purines De novo biosynthesis Antibodies Production Magnesium 4Fe-4S Magnesium Magnesium Purine De Novo Synthesis Pathway Cytosol Mercaptropurine is converted into many metabolites through multi series of reactions. Thiodeoxyguanosine-5'- triphosphate can be incorporated into DNA synthesis causing errors in the DNA. Due to this, the cell cannot replicate itself, killing it by apoptosis. Thioguanosine 5'-triphosphate inhibits ras-related C3 botulinum toxin substrate 1 which is a signalling GTPase protein found in cells that regulates numerous cellular events. Some of the regulated events include replication, cell-cell adhesion, epithelial differentiation, apoptosis, and more. Inhibition of ras-related C3 botulinum toxin substrate 1 induces apoptosis of the cell. 6-Methylthiopurine 5'-monophosphate ribonucleotide inhibits amidophosphoribosyltransferase which catalyzes the reaction between phosphoribosyl pyrophosphate and glutamine into phosphoribosylamine and glutamic acid. This reaction is one of the first in the purine de novo synthesis pathway. Inhibiting this step affects the downstream reactions that produce adenine, adenosine, guanine and guanosine. Since the purine de novo synthesis pathway is blocked, adenine, adenosine, guanine and guanosine aren't being produced. Since they are important compounds in the synthesis of DNA and RNA, replication and transcription are halted and the cell dies. T and B lymphocytes require purines being produced through the purine de novo pathway in order to proliferate and create antibodies. Unlike other cells who can obtain DNA/RNA building blocks through other means, T and B lymphocytes are reliant on this pathway. T or B Cell Blood vessel T or B Cell Apoptosis The apoptosis of the T and B cells results in the immunosuppression of the patient by the death of the B and T cells and, also, by the arrest of antibodies production. Due to the arrest in De novo purine synthesis, DNA and RNA errors and the inhibition of the Rac1 activity, the metabolites of mercaptopurine causes the cell cytotoxicity, leading to the apoptosis of the B and T cells.
PPAT RAC1 SLC29A1 SLC28A2 HPRT1 IMPDH1 GMPS PRPS1L1 GART GART PFAS PNP PNP TPMT 6- Methylthiopurine 5'- monophosphate ribonucleotide Thioguanosine 5'-triphosphate Thiodeoxyguanosine- 5'- triphosphate Guanosine Guanine Adenine Phosphoribosylformylglycineamidine Mercaptopurine Mercaptopurine Mercaptopurine Phosphoribosyl pyrophosphate 6- Thioinosine- 5'- monophosphate NAD Water Thioxanthine monophosphate NADH L-Glutamine Water Adenosine triphosphate 6-Thioguanosine monophosphate Adenosine monophosphate Pyrophosphate Thioguanosine 5'-diphosphate Thiodeoxyguanosine 5'-diphosphate D-Ribose 5-phosphate Adenosine triphosphate Phosphoribosyl pyrophosphate Adenosine monophosphate 5- Phosphoribosylamine Pyrophosphate L-Glutamic acid L-Glutamine Water Adenosine triphosphate Glycine Adenosine diphosphate Phosphate Glycineamideribotide 10- Formyltetrahydrofolate Tetrahydrofolic acid 5'- Phosphoribosyl- N- formylglycinamide Adenosine triphosphate L-Glutamine Water Adenosine diphosphate Phosphoric acid L-Glutamic acid Adenosine Phosphate Ribose 1-phosphate Phosphate Ribose 1-phosphate S- Adenosylmethionine S- Adenosylhomocysteine Sodium Sodium DNA Synthesis Regulation of Apoptosis of Activated T Cells DNA and RNA Synthesis DNA and RNA Synthesis DNA and RNA Synthesis Purines De novo biosynthesis Antibodies Production
PPAT RAC1 SLC29A1 SLC28A2 HPRT1 IMPDH1 GMPS PRPS1L1 GART GART PFAS PNP PNP TPMT 6M5MR ToGS5TP Th-5'-t Guo Guanine Adenine FGAM Mcapprn Mcapprn Mcapprn PRPP 6T5M NAD H2O ThioMP NADH Gln H2O ATP 6TgsMP AMP PPi ToGS5DP ToDG5DP DRib-5P ATP PRPP AMP 5-PPRSA PPi Glu Gln H2O ATP Gly ADP Pi Glyadbt 10-FTHF THFA 5PPNFG ATP Gln H2O ADP PhosfrA Glu Adenosi Pi Rib-1P Pi Rib-1P SAMe SAH Na+ Na+ K+ DNA Syn R o A o D a R S D a R S D a R S P D n b Ant Pro Mg2+ 4Fe-4S Mg2+ Mg2+ Purine De Novo Synthesis Pathway Cytosol Mercaptropurine is converted into many metabolites through multi series of reactions. Thiodeoxyguanosine-5'- triphosphate can be incorporated into DNA synthesis causing errors in the DNA. Due to this, the cell cannot replicate itself, killing it by apoptosis. Thioguanosine 5'-triphosphate inhibits ras-related C3 botulinum toxin substrate 1 which is a signalling GTPase protein found in cells that regulates numerous cellular events. Some of the regulated events include replication, cell-cell adhesion, epithelial differentiation, apoptosis, and more. Inhibition of ras-related C3 botulinum toxin substrate 1 induces apoptosis of the cell. 6-Methylthiopurine 5'-monophosphate ribonucleotide inhibits amidophosphoribosyltransferase which catalyzes the reaction between phosphoribosyl pyrophosphate and glutamine into phosphoribosylamine and glutamic acid. This reaction is one of the first in the purine de novo synthesis pathway. Inhibiting this step affects the downstream reactions that produce adenine, adenosine, guanine and guanosine. Since the purine de novo synthesis pathway is blocked, adenine, adenosine, guanine and guanosine aren't being produced. Since they are important compounds in the synthesis of DNA and RNA, replication and transcription are halted and the cell dies. T and B lymphocytes require purines being produced through the purine de novo pathway in order to proliferate and create antibodies. Unlike other cells who can obtain DNA/RNA building blocks through other means, T and B lymphocytes are reliant on this pathway. T or B Cell Blood vessel T or B Cell Apoptosis The apoptosis of the T and B cells results in the immunosuppression of the patient by the death of the B and T cells and, also, by the arrest of antibodies production. Due to the arrest in De novo purine synthesis, DNA and RNA errors and the inhibition of the Rac1 activity, the metabolites of mercaptopurine causes the cell cytotoxicity, leading to the apoptosis of the B and T cells.
PPAT RAC1 SLC29A1 SLC28A2 HPRT1 IMPDH1 GMPS PRPS1L1 GART GART PFAS PNP PNP TPMT 6M5MR ToGS5TP Th-5'-t Guo Guanine Adenine FGAM Mcapprn Mcapprn Mcapprn PRPP 6T5M NAD H2O ThioMP NADH Gln H2O ATP 6TgsMP AMP Ppi ToGS5DP ToDG5DP DRib-5P ATP PRPP AMP 5-PPRSA Ppi Glu Gln H2O ATP Gly ADP Pi Glyadbt 10-FTHF THFA 5PPNFG ATP Gln H2O ADP PhosfrA Glu Adenosi Pi Rib-1P Pi Rib-1P SAMe SAH Na+ Na+ DNA Syn R o A o D a R S D a R S D a R S P D n b Ant Pro