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5- hydroxytryptamine receptor 2A Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Loxapine Ca+ Serotonin Loxapine L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ psychotic effects Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Loxapine also acts as an antagonist to Dopamine 1 receptor and over 30 other targets Loxapine is taken orally and absorbed from the gastrointestinal tract passive diffusion
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Calcium Serotonin Serotonin Loxapine Calcium Serotonin Loxapine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium Gq signaling cascade
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca+ 5-HT 5-HT Loxapin Ca+ 5-HT Loxapin Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ Fe2+ Pyr-5'P Gq si c Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ psychotic effects Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Loxapine also acts as an antagonist to Dopamine 1 receptor and over 30 other targets Loxapine is taken orally and absorbed from the gastrointestinal tract passive diffusion
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca2+ 5-HT 5-HT Loxapin Ca2+ 5-HT Loxapin Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ Gq si c