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D(2) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Dopamine Ca+ Mesoridazine Ca+ Dopamine Dopamine Mesoridazine Mesoridazine L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate GDP Gi signaling cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Mesoridazine is a D2 receptor antagonist. It acts indirectly on reticular formation. ↓ Positive, negative and cognitive symptoms of schizophrenia Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. Mesoridazine is taken orally
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH GNAS Dopamine Calcium Mesoridazine Calcium Dopamine Dopamine Mesoridazine Mesoridazine L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Guanosine diphosphate Gi signaling cascade
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH GNAS LDP Ca+ TPS23 Ca+ LDP LDP TPS23 TPS23 L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P GDP Gi si c Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Mesoridazine is a D2 receptor antagonist. It acts indirectly on reticular formation. ↓ Positive, negative and cognitive symptoms of schizophrenia Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. Mesoridazine is taken orally
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH GNAS LDP Ca2+ TPS23 Ca2+ LDP LDP TPS23 TPS23 L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ GDP Gi si c