Loader
Loading Pathway...
D(2) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Amisulpride Ca+ Dopamine Dopamine Amisulpride Amisulpride L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate GDP Gi signaling cascade Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Amisulpride is a D2/D3 receptor antagonist. Dopamine receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia. ↓ Positive, negative and cognitive symptoms of schizophrenia Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier chemoreceptor trigger zone ↓ nausea and vomitting passive diffusion dopamine receptors in the chemoreceptor trigger zone (area postrema) is stimulated to cause nausea and vomiting Amisulpride acts as an antagonist to D2 receptors present in the vagus nerves from brain to gut Amisulpride is taken orally and absorbed from the gastrointestinal tract.
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca+ Amisulp Ca+ LDP LDP Amisulp Amisulp L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P GDP Gi si c GNAS Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Amisulpride is a D2/D3 receptor antagonist. Dopamine receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia. ↓ Positive, negative and cognitive symptoms of schizophrenia Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier chemoreceptor trigger zone ↓ nausea and vomitting passive diffusion dopamine receptors in the chemoreceptor trigger zone (area postrema) is stimulated to cause nausea and vomiting Amisulpride acts as an antagonist to D2 receptors present in the vagus nerves from brain to gut Amisulpride is taken orally and absorbed from the gastrointestinal tract.
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca2+ Amisulp Ca2+ LDP LDP Amisulp Amisulp L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ GDP Gi si c GNAS