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5- hydroxytryptamine receptor 2A Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Tiapride Ca+ Serotonin Tiapride Tiapride L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ Negative symptoms of schizophrenia Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Tiapride binds to 5HT2A where it reduces negative symptoms of psychosis, agitation and aggression reduces agitation and aggression Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Passive Diffusion Tiapride taken orally is absorbed from the gastrointestinal tract
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Calcium Serotonin Serotonin Tiapride Calcium Serotonin Tiapride Tiapride L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium Gq signaling cascade
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca+ 5-HT 5-HT Tiaprid Ca+ 5-HT Tiaprid Tiaprid Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ Fe2+ Pyr-5'P Gq si c Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ Negative symptoms of schizophrenia Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Tiapride binds to 5HT2A where it reduces negative symptoms of psychosis, agitation and aggression reduces agitation and aggression Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Passive Diffusion Tiapride taken orally is absorbed from the gastrointestinal tract
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca2+ 5-HT 5-HT Tiaprid Ca2+ 5-HT Tiaprid Tiaprid Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ Gq si c