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Pathway Description
Reteplase Action Pathway (new)
Homo sapiens
Drug Action Pathway
Reteplase is a plasminogen activator that is created as a purified form of human tissue, also known as Retavase that is used in emergencies such as myocardial infarction, ischemic stroke and pulmonary emboli. Reteplase is administered intravenously and travels through the bloodstream and acts on plasminogen cleaving an arginine-valine bond converting it to its active form plasmin. Plasmin then goes to act on the fibrin matrix and degrades it into its products eliminating the blood clot.
References
Reteplase Pathway (new) References
Mohammadi E, Seyedhosseini-Ghaheh H, Mahnam K, Jahanian-Najafabadi A, Mir Mohammad Sadeghi H: Reteplase: Structure, Function, and Production. Adv Biomed Res. 2019 Mar 20;8:19. doi: 10.4103/abr.abr_169_18. eCollection 2019.
Pubmed: 31016177
Noble S, McTavish D: Reteplase. A review of its pharmacological properties and clinical efficacy in the management of acute myocardial infarction. Drugs. 1996 Oct;52(4):589-605. doi: 10.2165/00003495-199652040-00012.
Pubmed: 8891469
Wooster MB, Luzier AB: Reteplase: a new thrombolytic for the treatment of acute myocardial infarction. Ann Pharmacother. 1999 Mar;33(3):318-24. doi: 10.1345/aph.18006.
Pubmed: 10200858
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