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Pathway Description
Streptokinase Action Pathway (new)
Homo sapiens
Drug Action Pathway
Streptokinase is a bacterial protein that is fibrinolytic and used to break down blood clots in myocardial infarction, pulmonary embolism and venous thromboembolism. It is administered intravenously and travels through the bloodstream to target blood clots. Streptokinase does this by converting plasminogen to its active form plasmin, by cleaving an arginine-valine bond. Once plasmin is activated it breaks down the fibrin mesh of the blood clot turning it into degradation products. Due to the anticoagulant and antiplatelet activity, herbs and supplements with a similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.
References
Streptokinase Pathway (new) References
Edwards Z, Nagalli S: Streptokinase.
Pubmed: 31985996
Banerjee A, Chisti Y, Banerjee UC: Streptokinase--a clinically useful thrombolytic agent. Biotechnol Adv. 2004 Feb;22(4):287-307. doi: 10.1016/j.biotechadv.2003.09.004.
Pubmed: 14697452
Kunamneni A, Abdelghani TT, Ellaiah P: Streptokinase--the drug of choice for thrombolytic therapy. J Thromb Thrombolysis. 2007 Feb;23(1):9-23. doi: 10.1007/s11239-006-9011-x.
Pubmed: 17111203
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