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D(2) dopamine receptor D(3) dopamine receptor D(2) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Vesicle- associated membrane protein 2 Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Lisuride Lisuride Ca+ Dopamine Lisuride Lisuride Dopamine L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi Signaling Cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Lisuride increases dopamine activity in the brain Neuronal excitability Lisuride has affinity for D2, D3 receptors and moderate affinity for D4 receptors Brain Nigrostriatal pathway Blood vessel - blood brain barrier Passive Diffusion Caudate-Putamen Lisuride is administered orally and absorbed from the gastrointestinal tract
DRD2 DRD3 DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 VAMP2 SLC18A2 DDC TH Dopamine Calcium Lisuride Lisuride Calcium Dopamine Lisuride Lisuride Dopamine L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi Signaling Cascade
DRD2 DRD3 DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 VAMP2 SLC18A2 DDC TH LDP Ca+ Lisurid Lisurid Ca+ LDP Lisurid Lisurid LDP L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi Si C Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Lisuride increases dopamine activity in the brain Neuronal excitability Lisuride has affinity for D2, D3 receptors and moderate affinity for D4 receptors Brain Nigrostriatal pathway Blood vessel - blood brain barrier Passive Diffusion Caudate-Putamen Lisuride is administered orally and absorbed from the gastrointestinal tract
DRD2 DRD3 DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 VAMP2 SLC18A2 DDC TH LDP Ca2+ Lisurid Lisurid Ca2+ LDP Lisurid Lisurid LDP L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Gi Si C