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Pathway Description
Ardeparin Action Pathway (new)
Homo sapiens
Drug Action Pathway
Ardeparin is a low molecular weight heparin anticoagulant, also known as Normiflo, used to prevent postoperative venous thrombosis. It is created from heparin extracted from porcine intestinal mucosa that has gone through peroxide degradation. Ardeparin acts on antithrombin III, which leads to the inactivation of factor Xa and thrombin inhibiting thrombosis. It is administered subcutaneously and travels to its target in the bloodstream. Some signs of overdose may include excessive bleeding and bruising. Due to its anticoagulant nature herbs and supplements with similar activity should be avoided such as ginseng, ginkgo, ginger and garlic.
References
Ardeparin Pathway (new) References
Heit JA, Berkowitz SD, Bona R, Cabanas V, Corson JD, Elliott CG, Lyons R: Efficacy and safety of low molecular weight heparin (ardeparin sodium) compared to warfarin for the prevention of venous thromboembolism after total knee replacement surgery: a double-blind, dose-ranging study. Ardeparin Arthroplasty Study Group. Thromb Haemost. 1997 Jan;77(1):32-8.
Pubmed: 9031445
Heit JA, Elliott CG, Trowbridge AA, Morrey BF, Gent M, Hirsh J: Ardeparin sodium for extended out-of-hospital prophylaxis against venous thromboembolism after total hip or knee replacement. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000 Jun 6;132(11):853-61. doi: 10.7326/0003-4819-132-11-200006060-00002.
Pubmed: 10836911
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