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cAMP-dependent protein kinase type II-beta regulatory subunit cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit D(2) dopamine receptor Adenylate cyclase type 2 Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Guanine nucleotide- binding protein G(i) subunit alpha-1 Synaptic vesicular amine transporter Voltage- dependent calcium channel subunit alpha-2/delta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent N-type calcium channel subunit alpha-1B Sodium- dependent dopamine transporter Tyrosine 3-monooxygenase Aromatic-L- amino-acid decarboxylase cAMP Ca+ Dopamine Dopamine Dihydroergocryptine Dopamine Ca+ Dihydroergocryptine Dihydroergocryptine L-Tyrosine L-Dopa CO2 ATP PPi Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Neuronal Excitability Magnesium Activation of D2 dopamine receptors activates the Gi signalling cascade which leads to increased cAMP. Presynaptic Neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Dopamine is produced in the Ventral Tegmental Area of the brain Nigrostriatal pathway Synapse Blood vessel - Blood Brain Barrier Brain Dihydroergocryptine is taken orally and absorbed from the gastrointestinal tract. passive diffusion
PRKAR2B PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2A DRD2 ADCY2 GNAS GNAI1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B SLC6A3 TH DDC cAMP Calcium Dopamine Dopamine Dihydroergocryptine Dopamine Calcium Dihydroergocryptine Dihydroergocryptine L-Tyrosine L-Dopa Carbon dioxide Adenosine triphosphate Pyrophosphate Sodium Sodium Neuronal Excitability
PRKAR2B PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2A DRD2 ADCY2 GNAS GNAI1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B SLC6A3 TH DDC cAMP Ca+ LDP LDP Dihyd LDP Ca+ Dihyd Dihyd Tyr L-Dopa CO2 ATP PPi Na+ Na+ Fe2+ Pyr-5'P Neu Exc Mg2+ Activation of D2 dopamine receptors activates the Gi signalling cascade which leads to increased cAMP. Presynaptic Neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Dopamine is produced in the Ventral Tegmental Area of the brain Nigrostriatal pathway Synapse Blood vessel - Blood Brain Barrier Brain Dihydroergocryptine is taken orally and absorbed from the gastrointestinal tract. passive diffusion
PRKAR2B PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2A DRD2 ADCY2 GNAS GNAI1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B SLC6A3 TH DDC cAMP Ca2+ LDP LDP Dihyd LDP Ca2+ Dihyd Dihyd Tyr L-Dopa CO2 ATP Ppi Na+ Na+ Neu Exc