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Pathway Description
Agomelatine Serotonin Antagonist Action Pathway
Homo sapiens
Drug Action Pathway
Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors and promotes dopamine and norepinephrine release. Agomelatine is indicated to treat major depressive episodes in adults. It is an atypical antidepressant.
References
Agomelatine Serotonin Antagonist Pathway References
Sheffler ZM, Patel P, Abdijadid S: Antidepressants.
Pubmed: 30844209
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Sansone RA, Sansone LA: Agomelatine: a novel antidepressant. Innov Clin Neurosci. 2011 Nov;8(11):10-4.
Pubmed: 22191083
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