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cAMP-dependent protein kinase type II-beta regulatory subunit cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit D(2) dopamine receptor Adenylate cyclase type 5 Synaptic vesicular amine transporter Sodium- dependent dopamine transporter Voltage- dependent calcium channel subunit alpha-2/delta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent N-type calcium channel subunit alpha-1B Tyrosine 3-monooxygenase Aromatic-L- amino-acid decarboxylase cAMP Ca+ Dopamine Dopamine Asenapine Dopamine Ca+ Asenapine Asenapine L-Tyrosine L-Dopa CO2 Na+ Na+ ATP Fe2+ Pyridoxal 5'-phosphate Guanine nucleotide- binding protein G(i) subunit alpha-1 Neuronal Excitability Activation of D2 dopamine receptors activates the Gi signalling cascade which leads to reduced cAMP. and PKA Reward Pathway Presynaptic Neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Dopamine is produced in the Ventral Tegmental Area of the brain Prefrontal Cortex Synapse Increased dopamine activates D2 dopamine receptor in the limbic system Blood-Brain Barrier Diffusion Asenapine is administered as a sublingual tablet
PRKAR2B PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2A DRD2 ADCY5 SLC18A2 SLC6A3 CACNA2D1 CACNA2D2 CACNA1B TH DDC cAMP Calcium Dopamine Dopamine Asenapine Dopamine Calcium Asenapine Asenapine L-Tyrosine L-Dopa Carbon dioxide Sodium Sodium Adenosine triphosphate GNAI1 Neuronal Excitability
PRKAR2B PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2A DRD2 ADCY5 SLC18A2 SLC6A3 CACNA2D1 CACNA2D2 CACNA1B TH DDC cAMP Ca+ LDP LDP Asena LDP Ca+ Asena Asena Tyr L-Dopa CO2 Na+ Na+ ATP Fe2+ Pyr-5'P GNAI1 Neu Exc Activation of D2 dopamine receptors activates the Gi signalling cascade which leads to reduced cAMP. and PKA Reward Pathway Presynaptic Neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Dopamine is produced in the Ventral Tegmental Area of the brain Prefrontal Cortex Synapse Increased dopamine activates D2 dopamine receptor in the limbic system Blood-Brain Barrier Diffusion Asenapine is administered as a sublingual tablet
PRKAR2B PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2A DRD2 ADCY5 SLC18A2 SLC6A3 CACNA2D1 CACNA2D2 CACNA1B TH DDC cAMP Ca2+ LDP LDP Asena LDP Ca2+ Asena Asena Tyr L-Dopa CO2 Na+ Na+ ATP GNAI1 Neu Exc